Development of Smart Sensing Film with Nonbiofouling Properties for Potentiometric Detection of Local pH Changes Caused by Bacterial and Yeast Infections Around Orthopedic Implants

Abstract The local peri‐implant pH changes caused by sterile inflammation and bacterial fungal infections are studied herein. Then, a sensing electrode based on polyaniline poly(2‐methyl‐2‐oxazoline) titanium alloy support is developed for potentiometric detection of to enable early the aforementioned pathologies. infected endoprosthesis area shown have an average 0.79 units lower than aseptic sample. measurements individual pathogenic bacteria or yeast reveal that Escherichia coli decreased 1.24 units, Staphylococcus aureus 1.33 methicillin‐resistant from 7.2 5.6 during 10 h, followed subsequent increase 6.4. results statistically significant (α = 0.01). Pseudomonas aeruginosa not change levels. On other hand, has lowest recorded pH, which decreases 5.8 4.8. This difference in can be used identify nature infection. electrodes response between 5 8, with Nernstian slope −59.6/pH. contribute next generation biosensors.